Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study.
Identifieur interne : 002261 ( Main/Exploration ); précédent : 002260; suivant : 002262Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study.
Auteurs : Meletios A. Dimopoulos [Grèce] ; Philippe Moreau [France] ; Antonio Palumbo [Italie] ; Douglas Joshua [Australie] ; Ludek Pour [République tchèque] ; Roman Hájek [République tchèque] ; Thierry Facon [France] ; Heinz Ludwig [Autriche] ; Albert Oriol [Espagne] ; Hartmut Goldschmidt [Allemagne] ; Laura Rosi Ol [Espagne] ; Jan Straub [République tchèque] ; Aleksandr Suvorov [Russie] ; Carla Araujo [France] ; Elena Rimashevskaya [Russie] ; Tomas Pika [République tchèque] ; Gianluca Gaidano [Italie] ; Katja Weisel [Allemagne] ; Vesselina Goranova-Marinova [Bulgarie] ; Anthony Schwarer [Australie] ; Leonard Minuk [Canada] ; Tamás Masszi [Hongrie] ; Ievgenii Karamanesht [Ukraine] ; Massimo Offidani [Italie] ; Vania Hungria [Brésil] ; Andrew Spencer [Australie] ; Robert Z. Orlowski [États-Unis] ; Heidi H. Gillenwater [États-Unis] ; Nehal Mohamed [États-Unis] ; Shibao Feng [États-Unis] ; Wee-Joo Chng [Singapour]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2016.
Descripteurs français
- KwdFr :
- Anémie (), Bortézomib (administration et posologie), Bortézomib (effets indésirables), Dexaméthasone (administration et posologie), Dexaméthasone (effets indésirables), Femelle, Humains, Hypertension artérielle (), Myélome multiple (traitement médicamenteux), Mâle, Oligopeptides (administration et posologie), Oligopeptides (effets indésirables), Pneumopathie infectieuse (), Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Reprise du traitement, Sujet âgé, Survie sans rechute, Taux de survie, Thrombopénie (), Études de suivi.
- MESH :
- administration et posologie : Bortézomib, Dexaméthasone, Oligopeptides.
- effets indésirables : Bortézomib, Dexaméthasone, Oligopeptides, Protocoles de polychimiothérapie antinéoplasique.
- traitement médicamenteux : Myélome multiple.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Anémie, Femelle, Humains, Hypertension artérielle, Mâle, Pneumopathie infectieuse, Reprise du traitement, Sujet âgé, Survie sans rechute, Taux de survie, Thrombopénie, Études de suivi.
English descriptors
- KwdEn :
- Aged, Anemia (chemically induced), Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Bortezomib (administration & dosage), Bortezomib (adverse effects), Dexamethasone (administration & dosage), Dexamethasone (adverse effects), Disease-Free Survival, Female, Follow-Up Studies, Humans, Hypertension (chemically induced), Male, Multiple Myeloma (drug therapy), Oligopeptides (administration & dosage), Oligopeptides (adverse effects), Pneumonia (chemically induced), Retreatment, Survival Rate, Thrombocytopenia (chemically induced).
- MESH :
- chemical , administration & dosage : Bortezomib, Dexamethasone, Oligopeptides.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols, Bortezomib, Dexamethasone, Oligopeptides.
- chemically induced : Anemia, Hypertension, Pneumonia, Thrombocytopenia.
- drug therapy : Multiple Myeloma.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Retreatment, Survival Rate.
Abstract
Bortezomib with dexamethasone is a standard treatment option for relapsed or refractory multiple myeloma. Carfilzomib with dexamethasone has shown promising activity in patients in this disease setting. The aim of this study was to compare the combination of carfilzomib and dexamethasone with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma.
DOI: 10.1016/S1470-2045(15)00464-7
PubMed: 26671818
Affiliations:
- Allemagne, Australie, Autriche, Brésil, Bulgarie, Canada, Espagne, France, Grèce, Hongrie, Italie, Russie, République tchèque, Singapour, Ukraine, États-Unis
- Aquitaine, Attique (région), Bade-Wurtemberg, Bohême centrale, Californie, Catalogne, District de Karlsruhe, District fédéral central, Hauts-de-France, Hongrie centrale, Moravie, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Pays de la Loire, Piémont, Texas, Vienne (Autriche), État de São Paulo
- Athènes, Barcelone, Bayonne, Brno, Budapest, Heidelberg, Lille, Moscou, Nantes, Prague, São Paulo, Turin, Vienne (Autriche)
- Université nationale de Singapour
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Le document en format XML
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tchèque</country><wicri:regionArea>Vseobecna fakultni nemocnice v Praze, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Suvorov, Aleksandr" sort="Suvorov, Aleksandr" uniqKey="Suvorov A" first="Aleksandr" last="Suvorov">Aleksandr Suvorov</name><affiliation wicri:level="1"><nlm:affiliation>Hematological Department, First Republican Clinical Hospital of Udmurtia, Izhevsk, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Hematological Department, First Republican Clinical Hospital of Udmurtia, Izhevsk</wicri:regionArea><wicri:noRegion>Izhevsk</wicri:noRegion></affiliation></author><author><name sortKey="Araujo, Carla" sort="Araujo, Carla" uniqKey="Araujo C" first="Carla" last="Araujo">Carla Araujo</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier de la Cote Basque, Bayonne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier de la Cote Basque, Bayonne</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bayonne</settlement></placeName></affiliation></author><author><name sortKey="Rimashevskaya, Elena" sort="Rimashevskaya, Elena" uniqKey="Rimashevskaya E" first="Elena" last="Rimashevskaya">Elena Rimashevskaya</name><affiliation wicri:level="3"><nlm:affiliation>Semashko Central Clinical Hospital, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Semashko Central Clinical Hospital, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name><affiliation 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Plovdiv</wicri:regionArea><wicri:noRegion>Plovdiv</wicri:noRegion></affiliation></author><author><name sortKey="Schwarer, Anthony" sort="Schwarer, Anthony" uniqKey="Schwarer A" first="Anthony" last="Schwarer">Anthony Schwarer</name><affiliation wicri:level="1"><nlm:affiliation>Box Hill Hospital, Box Hill, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Box Hill Hospital, Box Hill, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Minuk, Leonard" sort="Minuk, Leonard" uniqKey="Minuk L" first="Leonard" last="Minuk">Leonard Minuk</name><affiliation wicri:level="1"><nlm:affiliation>London Health Sciences Centre, Western University, London, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>London Health Sciences Centre, Western University, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Masszi, Tamas" sort="Masszi, Tamas" uniqKey="Masszi T" first="Tamás" last="Masszi">Tamás Masszi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Stem-cell Transplant, St Istvan and St Laszlo Hospital of Budapest, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Haematology and Stem-cell Transplant, St Istvan and St Laszlo Hospital of Budapest, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Karamanesht, Ievgenii" sort="Karamanesht, Ievgenii" uniqKey="Karamanesht I" first="Ievgenii" last="Karamanesht">Ievgenii Karamanesht</name><affiliation wicri:level="1"><nlm:affiliation>Kyiv Center for Bone Marrow Transplantation, Kyiv, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Kyiv Center for Bone Marrow Transplantation, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation></author><author><name sortKey="Offidani, Massimo" sort="Offidani, Massimo" uniqKey="Offidani M" first="Massimo" last="Offidani">Massimo Offidani</name><affiliation wicri:level="1"><nlm:affiliation>Clinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi di Ancona, Ancona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi di Ancona, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Hungria, Vania" sort="Hungria, Vania" uniqKey="Hungria V" first="Vania" last="Hungria">Vania Hungria</name><affiliation wicri:level="3"><nlm:affiliation>Irmandade da Santa Casa de Misericórdia de Sao Paulo, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Irmandade da Santa Casa de Misericórdia de Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="1"><nlm:affiliation>Alfred Health-Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Alfred Health-Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z" last="Orlowski">Robert Z. Orlowski</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas MD Anderson Cancer Center, The University of Texas, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gillenwater, Heidi H" sort="Gillenwater, Heidi H" uniqKey="Gillenwater H" first="Heidi H" last="Gillenwater">Heidi H. Gillenwater</name><affiliation wicri:level="2"><nlm:affiliation>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mohamed, Nehal" sort="Mohamed, Nehal" uniqKey="Mohamed N" first="Nehal" last="Mohamed">Nehal Mohamed</name><affiliation wicri:level="2"><nlm:affiliation>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Feng, Shibao" sort="Feng, Shibao" uniqKey="Feng S" first="Shibao" last="Feng">Shibao Feng</name><affiliation wicri:level="2"><nlm:affiliation>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chng, Wee Joo" sort="Chng, Wee Joo" uniqKey="Chng W" first="Wee-Joo" last="Chng">Wee-Joo Chng</name><affiliation wicri:level="4"><nlm:affiliation>National University Cancer Institute, National University Health System, Singapore and Cancer Science Institute of Singapore, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Cancer Institute, National University Health System, Singapore and Cancer Science Institute of Singapore, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26671818</idno><idno type="pmid">26671818</idno><idno type="doi">10.1016/S1470-2045(15)00464-7</idno><idno type="wicri:Area/PubMed/Corpus">002396</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002396</idno><idno type="wicri:Area/PubMed/Curation">002350</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002350</idno><idno type="wicri:Area/PubMed/Checkpoint">002350</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002350</idno><idno type="wicri:Area/Ncbi/Merge">002E73</idno><idno type="wicri:Area/Ncbi/Curation">002E73</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E73</idno><idno type="wicri:Area/Main/Merge">002260</idno><idno type="wicri:Area/Main/Curation">002261</idno><idno type="wicri:Area/Main/Exploration">002261</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study.</title><author><name sortKey="Dimopoulos, Meletios A" sort="Dimopoulos, Meletios A" uniqKey="Dimopoulos M" first="Meletios A" last="Dimopoulos">Meletios A. Dimopoulos</name><affiliation wicri:level="3"><nlm:affiliation>School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: mdimop@med.uoa.gr.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>School of Medicine, National and Kapodistrian University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name><affiliation wicri:level="3"><nlm:affiliation>University of Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation wicri:level="3"><nlm:affiliation>University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Joshua, Douglas" sort="Joshua, Douglas" uniqKey="Joshua D" first="Douglas" last="Joshua">Douglas Joshua</name><affiliation wicri:level="1"><nlm:affiliation>Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Prince Alfred Hospital, Camperdown, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Pour, Ludek" sort="Pour, Ludek" uniqKey="Pour L" first="Ludek" last="Pour">Ludek Pour</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Brno, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Brno, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Hajek, Roman" sort="Hajek, Roman" uniqKey="Hajek R" first="Roman" last="Hájek">Roman Hájek</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava</wicri:regionArea><wicri:noRegion>Ostrava</wicri:noRegion></affiliation></author><author><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name><affiliation wicri:level="3"><nlm:affiliation>CHRU Lille Hôpital Claude Huriez, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU Lille Hôpital Claude Huriez, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation wicri:level="3"><nlm:affiliation>Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Oriol, Albert" sort="Oriol, Albert" uniqKey="Oriol A" first="Albert" last="Oriol">Albert Oriol</name><affiliation wicri:level="3"><nlm:affiliation>Institut Català d'Oncologia, Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut Català d'Oncologia, Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Goldschmidt, Hartmut" sort="Goldschmidt, Hartmut" uniqKey="Goldschmidt H" first="Hartmut" last="Goldschmidt">Hartmut Goldschmidt</name><affiliation wicri:level="3"><nlm:affiliation>Heidelberg Medical University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Heidelberg Medical University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Rosi Ol, Laura" sort="Rosi Ol, Laura" uniqKey="Rosi Ol L" first="Laura" last="Rosi Ol">Laura Rosi Ol</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Straub, Jan" sort="Straub, Jan" uniqKey="Straub J" first="Jan" last="Straub">Jan Straub</name><affiliation wicri:level="3"><nlm:affiliation>Vseobecna fakultni nemocnice v Praze, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Vseobecna fakultni nemocnice v Praze, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Suvorov, Aleksandr" sort="Suvorov, Aleksandr" uniqKey="Suvorov A" first="Aleksandr" last="Suvorov">Aleksandr Suvorov</name><affiliation wicri:level="1"><nlm:affiliation>Hematological Department, First Republican Clinical Hospital of Udmurtia, Izhevsk, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Hematological Department, First Republican Clinical Hospital of Udmurtia, Izhevsk</wicri:regionArea><wicri:noRegion>Izhevsk</wicri:noRegion></affiliation></author><author><name sortKey="Araujo, Carla" sort="Araujo, Carla" uniqKey="Araujo C" first="Carla" last="Araujo">Carla Araujo</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier de la Cote Basque, Bayonne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier de la Cote Basque, Bayonne</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bayonne</settlement></placeName></affiliation></author><author><name sortKey="Rimashevskaya, Elena" sort="Rimashevskaya, Elena" uniqKey="Rimashevskaya E" first="Elena" last="Rimashevskaya">Elena Rimashevskaya</name><affiliation wicri:level="3"><nlm:affiliation>Semashko Central Clinical Hospital, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Semashko Central Clinical Hospital, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematooncology, University Hospital Olomouc, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Hematooncology, University Hospital Olomouc, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Gaidano, Gianluca" sort="Gaidano, Gianluca" uniqKey="Gaidano G" first="Gianluca" last="Gaidano">Gianluca Gaidano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Weisel, Katja" sort="Weisel, Katja" uniqKey="Weisel K" first="Katja" last="Weisel">Katja Weisel</name><affiliation wicri:level="1"><nlm:affiliation>Universitatsklinikum Tubingen, Tubingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitatsklinikum Tubingen, Tubingen</wicri:regionArea><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Goranova Marinova, Vesselina" sort="Goranova Marinova, Vesselina" uniqKey="Goranova Marinova V" first="Vesselina" last="Goranova-Marinova">Vesselina Goranova-Marinova</name><affiliation wicri:level="1"><nlm:affiliation>University Multiprofile Hospital for Active Treatment Sveti Georgi and Hematology Clinic, Plovdiv, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>University Multiprofile Hospital for Active Treatment Sveti Georgi and Hematology Clinic, Plovdiv</wicri:regionArea><wicri:noRegion>Plovdiv</wicri:noRegion></affiliation></author><author><name sortKey="Schwarer, Anthony" sort="Schwarer, Anthony" uniqKey="Schwarer A" first="Anthony" last="Schwarer">Anthony Schwarer</name><affiliation wicri:level="1"><nlm:affiliation>Box Hill Hospital, Box Hill, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Box Hill Hospital, Box Hill, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Minuk, Leonard" sort="Minuk, Leonard" uniqKey="Minuk L" first="Leonard" last="Minuk">Leonard Minuk</name><affiliation wicri:level="1"><nlm:affiliation>London Health Sciences Centre, Western University, London, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>London Health Sciences Centre, Western University, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Masszi, Tamas" sort="Masszi, Tamas" uniqKey="Masszi T" first="Tamás" last="Masszi">Tamás Masszi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Stem-cell Transplant, St Istvan and St Laszlo Hospital of Budapest, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Haematology and Stem-cell Transplant, St Istvan and St Laszlo Hospital of Budapest, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Karamanesht, Ievgenii" sort="Karamanesht, Ievgenii" uniqKey="Karamanesht I" first="Ievgenii" last="Karamanesht">Ievgenii Karamanesht</name><affiliation wicri:level="1"><nlm:affiliation>Kyiv Center for Bone Marrow Transplantation, Kyiv, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Kyiv Center for Bone Marrow Transplantation, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation></author><author><name sortKey="Offidani, Massimo" sort="Offidani, Massimo" uniqKey="Offidani M" first="Massimo" last="Offidani">Massimo Offidani</name><affiliation wicri:level="1"><nlm:affiliation>Clinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi di Ancona, Ancona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi di Ancona, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Hungria, Vania" sort="Hungria, Vania" uniqKey="Hungria V" first="Vania" last="Hungria">Vania Hungria</name><affiliation wicri:level="3"><nlm:affiliation>Irmandade da Santa Casa de Misericórdia de Sao Paulo, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Irmandade da Santa Casa de Misericórdia de Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="1"><nlm:affiliation>Alfred Health-Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Alfred Health-Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z" last="Orlowski">Robert Z. Orlowski</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas MD Anderson Cancer Center, The University of Texas, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gillenwater, Heidi H" sort="Gillenwater, Heidi H" uniqKey="Gillenwater H" first="Heidi H" last="Gillenwater">Heidi H. Gillenwater</name><affiliation wicri:level="2"><nlm:affiliation>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mohamed, Nehal" sort="Mohamed, Nehal" uniqKey="Mohamed N" first="Nehal" last="Mohamed">Nehal Mohamed</name><affiliation wicri:level="2"><nlm:affiliation>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Feng, Shibao" sort="Feng, Shibao" uniqKey="Feng S" first="Shibao" last="Feng">Shibao Feng</name><affiliation wicri:level="2"><nlm:affiliation>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chng, Wee Joo" sort="Chng, Wee Joo" uniqKey="Chng W" first="Wee-Joo" last="Chng">Wee-Joo Chng</name><affiliation wicri:level="4"><nlm:affiliation>National University Cancer Institute, National University Health System, Singapore and Cancer Science Institute of Singapore, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Cancer Institute, National University Health System, Singapore and Cancer Science Institute of Singapore, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anemia (chemically induced)</term><term>Antineoplastic Combined Chemotherapy Protocols (adverse effects)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Bortezomib (administration & dosage)</term><term>Bortezomib (adverse effects)</term><term>Dexamethasone (administration & dosage)</term><term>Dexamethasone (adverse effects)</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Hypertension (chemically induced)</term><term>Male</term><term>Multiple Myeloma (drug therapy)</term><term>Oligopeptides (administration & dosage)</term><term>Oligopeptides (adverse effects)</term><term>Pneumonia (chemically induced)</term><term>Retreatment</term><term>Survival Rate</term><term>Thrombocytopenia (chemically induced)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anémie ()</term><term>Bortézomib (administration et posologie)</term><term>Bortézomib (effets indésirables)</term><term>Dexaméthasone (administration et posologie)</term><term>Dexaméthasone (effets indésirables)</term><term>Femelle</term><term>Humains</term><term>Hypertension artérielle ()</term><term>Myélome multiple (traitement médicamenteux)</term><term>Mâle</term><term>Oligopeptides (administration et posologie)</term><term>Oligopeptides (effets indésirables)</term><term>Pneumopathie infectieuse ()</term><term>Protocoles de polychimiothérapie antinéoplasique (effets indésirables)</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Reprise du traitement</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Taux de survie</term><term>Thrombopénie ()</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Bortezomib</term><term>Dexamethasone</term><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Bortézomib</term><term>Dexaméthasone</term><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Bortezomib</term><term>Dexamethasone</term><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Anemia</term><term>Hypertension</term><term>Pneumonia</term><term>Thrombocytopenia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Bortézomib</term><term>Dexaméthasone</term><term>Oligopeptides</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Myélome multiple</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Retreatment</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anémie</term><term>Femelle</term><term>Humains</term><term>Hypertension artérielle</term><term>Mâle</term><term>Pneumopathie infectieuse</term><term>Reprise du traitement</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Taux de survie</term><term>Thrombopénie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bortezomib with dexamethasone is a standard treatment option for relapsed or refractory multiple myeloma. Carfilzomib with dexamethasone has shown promising activity in patients in this disease setting. The aim of this study was to compare the combination of carfilzomib and dexamethasone with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Brésil</li><li>Bulgarie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Hongrie</li><li>Italie</li><li>Russie</li><li>République tchèque</li><li>Singapour</li><li>Ukraine</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>Bohême centrale</li><li>Californie</li><li>Catalogne</li><li>District de Karlsruhe</li><li>District fédéral central</li><li>Hauts-de-France</li><li>Hongrie centrale</li><li>Moravie</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Aquitaine</li><li>Pays de la Loire</li><li>Piémont</li><li>Texas</li><li>Vienne (Autriche)</li><li>État de São Paulo</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Bayonne</li><li>Brno</li><li>Budapest</li><li>Heidelberg</li><li>Lille</li><li>Moscou</li><li>Nantes</li><li>Prague</li><li>São Paulo</li><li>Turin</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Grèce"><region name="Attique (région)"><name sortKey="Dimopoulos, Meletios A" sort="Dimopoulos, Meletios A" uniqKey="Dimopoulos M" first="Meletios A" last="Dimopoulos">Meletios A. Dimopoulos</name></region></country><country name="France"><region name="Pays de la Loire"><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name></region><name sortKey="Araujo, Carla" sort="Araujo, Carla" uniqKey="Araujo C" first="Carla" last="Araujo">Carla Araujo</name><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name></country><country name="Italie"><region name="Piémont"><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name></region><name sortKey="Gaidano, Gianluca" sort="Gaidano, Gianluca" uniqKey="Gaidano G" first="Gianluca" last="Gaidano">Gianluca Gaidano</name><name sortKey="Offidani, Massimo" sort="Offidani, Massimo" uniqKey="Offidani M" first="Massimo" last="Offidani">Massimo Offidani</name></country><country name="Australie"><noRegion><name sortKey="Joshua, Douglas" sort="Joshua, Douglas" uniqKey="Joshua D" first="Douglas" last="Joshua">Douglas Joshua</name></noRegion><name sortKey="Schwarer, Anthony" sort="Schwarer, Anthony" uniqKey="Schwarer A" first="Anthony" last="Schwarer">Anthony Schwarer</name><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name></country><country name="République tchèque"><region name="Moravie"><name sortKey="Pour, Ludek" sort="Pour, Ludek" uniqKey="Pour L" first="Ludek" last="Pour">Ludek Pour</name></region><name sortKey="Hajek, Roman" sort="Hajek, Roman" uniqKey="Hajek R" first="Roman" last="Hájek">Roman Hájek</name><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name><name sortKey="Straub, Jan" sort="Straub, Jan" uniqKey="Straub J" first="Jan" last="Straub">Jan Straub</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Oriol, Albert" sort="Oriol, Albert" uniqKey="Oriol A" first="Albert" last="Oriol">Albert Oriol</name></region><name sortKey="Rosi Ol, Laura" sort="Rosi Ol, Laura" uniqKey="Rosi Ol L" first="Laura" last="Rosi Ol">Laura Rosi Ol</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Goldschmidt, Hartmut" sort="Goldschmidt, Hartmut" uniqKey="Goldschmidt H" first="Hartmut" last="Goldschmidt">Hartmut Goldschmidt</name></region><name sortKey="Weisel, Katja" sort="Weisel, Katja" uniqKey="Weisel K" first="Katja" last="Weisel">Katja Weisel</name></country><country name="Russie"><noRegion><name sortKey="Suvorov, Aleksandr" sort="Suvorov, Aleksandr" uniqKey="Suvorov A" first="Aleksandr" last="Suvorov">Aleksandr Suvorov</name></noRegion><name sortKey="Rimashevskaya, Elena" sort="Rimashevskaya, Elena" uniqKey="Rimashevskaya E" first="Elena" last="Rimashevskaya">Elena Rimashevskaya</name></country><country name="Bulgarie"><noRegion><name sortKey="Goranova Marinova, Vesselina" sort="Goranova Marinova, Vesselina" uniqKey="Goranova Marinova V" first="Vesselina" last="Goranova-Marinova">Vesselina Goranova-Marinova</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Minuk, Leonard" sort="Minuk, Leonard" uniqKey="Minuk L" first="Leonard" last="Minuk">Leonard Minuk</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Masszi, Tamas" sort="Masszi, Tamas" uniqKey="Masszi T" first="Tamás" last="Masszi">Tamás Masszi</name></region></country><country name="Ukraine"><noRegion><name sortKey="Karamanesht, Ievgenii" sort="Karamanesht, Ievgenii" uniqKey="Karamanesht I" first="Ievgenii" last="Karamanesht">Ievgenii Karamanesht</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Hungria, Vania" sort="Hungria, Vania" uniqKey="Hungria V" first="Vania" last="Hungria">Vania Hungria</name></region></country><country name="États-Unis"><region name="Texas"><name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z" last="Orlowski">Robert Z. Orlowski</name></region><name sortKey="Feng, Shibao" sort="Feng, Shibao" uniqKey="Feng S" first="Shibao" last="Feng">Shibao Feng</name><name sortKey="Gillenwater, Heidi H" sort="Gillenwater, Heidi H" uniqKey="Gillenwater H" first="Heidi H" last="Gillenwater">Heidi H. Gillenwater</name><name sortKey="Mohamed, Nehal" sort="Mohamed, Nehal" uniqKey="Mohamed N" first="Nehal" last="Mohamed">Nehal Mohamed</name></country><country name="Singapour"><noRegion><name sortKey="Chng, Wee Joo" sort="Chng, Wee Joo" uniqKey="Chng W" first="Wee-Joo" last="Chng">Wee-Joo Chng</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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